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The Science of Hair Loss, and Some Hope I DigT Dinosaurs Stegosaurus Skeleton Excavation A $24.99 Ace-150 Metal Detector $179.00 e-Newsletter Sign Up Amazing Images RSS Feed Discussion Board Job Search Log In Register Amazing Images: Upload Your Cool Pictures Now! Top Science Stories of 2005: A Year of Incredible Impact First Picture of Living Human Retina Reveals Surprise The Human Brain Seen as Master of Time Infant Masturbation Often Misdiagnosed CDC: Older Baby Boomers Plagued by High Blood Pressure and Obesity Deadly Ecosystem ... In Your Pillow Why You Can't Tickle Yourself World Trivia Intelligent Design: An Ambiguous Assault on Evolution Top 10 Missing Links Top 10 Creation Myths 101 Amazing Earth Facts The Science of Hair Loss, and Some Hope By Malcolm Ritter Associated Press posted: 15 November 2005 09:16 am ET Untitled Document Look around a crowd, and you'll see that lots of middle-aged men are losing their hair. As Baby Boomers, they have every right to demand, What is science doing about this? Quite a bit, it turns out. A British company, for example, says five guys are walking around with hundreds more hairs than they had before, thanks to an early test of what's been called hair cloning. An American outfit hopes to start testing a similar approach next year. Other scientists are tracking down genes that make some men susceptible to hair loss, and struggling to understand the mysterious biology behind it. For example, how can men lose hair on the top of their heads while their beards and even eyelashes keep going strong? Black men are far less susceptible, but about a third of 30-year-old white men have signs of what doctors call male-pattern baldness. By the time they're 50, about half of them do. The condition creeps across the head like three tiny armies bent on deforestation: one starting at the back, and two making inroads from the front. Sure, some men say bald is beautiful. And others can smear on minoxidil (Rogaine) or take Propecia pills, or get hair transplants. In fact, right now is "the best time in history to be going bald, because there's an awful lot of things that can be done,'' says Dr. Ken Washenik of the Aderans Research Institute in Philadelphia, which is investigating the "hair cloning'' approach. But the drugs don't help everybody, and not everyone is interested in a transplant. So there's room for new approaches. To understand the search for new treatments, it helps to know a little about hair and male pattern baldness. (Women can also get hormone-induced baldness like this, but it's not clear if it's really the same condition). Everybody starts out with a lifetime supply of about 100,000 follicles on the scalp, each primed to produce a single hair shaft. Normally, any given follicle pumps out that shaft for two years to six years, then takes a break for a few weeks. Then it sheds that hair, and starts the cycle over again. Each day, we lose about 100 hairs this way. No big deal; about an equal number of follicles enter the growth phase on the same day, and at any one time about 90 percent to 95 percent of the follicles are busy growing new hair. But in some men, in selected places on the scalp, this orderly process goes awry. The hair-growing phase gets progressively shorter and the resting phase gets longer. So the resulting hairs get shorter and shorter with each trip through the cycle. Eventually, they don't even poke out through the scalp. What's more, affected follicles take longer to start growing hair again after they've shed the last one. And they shrink, so the hair they produce is finer. On your head, it's like replacing mighty trees with saplings. And the total number of remaining hairs slips by about 5 percent a year. What causes this? The full picture isn't known, but it clearly involves a combination of genetic susceptibility and hormones, including testosterone. Researchers are eager to identify the biochemical actors within follicles that could be manipulated to fight baldness. As for genetics, some studies have implicated a particular gene that may be necessary to get the condition but not sufficient to produce baldness on its own, said Stephen Harrap of the University of Melbourne in Australia. In all, it might take inheriting certain versions of about five genes to get the condition, like getting a bad poker hand, suggested Rodney Sinclair of the university. In England, meanwhile, a company called Intercytex has just begun human studies of an approach sometimes called hair cloning. It focuses on a particular kind of cell, found at the base of the follicle, that can team up with skin cells to produce new follicles. Here's the idea: Extract some cells from the areas of a man's head that resist balding, put them in a lab dish and expand their numbers by thousands of times. Then inject these new cells back into the scalp, where they'll work with skin cells to form new follicles. So, unlike transplants, the guy actually ends up with more hairs than he started with. The company has recently tested this on seven men with thinning hair due to male pattern baldness, and five of them gained hair, says Intercytex chief scientific officer Paul Kemp. This was just an initial study to look for side effects like inflammation, Kemp says, and no such problems appeared. Not that this restored a full head of hair. The treated areas were just the size of a quarter, and covered places that already had hair, rather than bald spots. "We didn't want to create these weird and wonderful patterns on their head,'' Kemp said. "It's such a small area in the hairy area anyway, I would be surprised if they really knew any difference.'' Eventually, if further studies go well, the technique could allow hair transplant surgeons to cover more of a bald head, Kemp said. The next round of human research is expected to start next summer. Someday, men might avoid transplants altogether, just getting periodic shots of their own cells to counterbalance their hair loss. "You would be going thin, and you'd be maintained,'' Kemp said. "Sometime in the future, I think baldness will be a choice rather than something you have to suffer,'' said Kemp. "Any bald people will have chosen to be bald.'' Within five years, Kemp says, his company may have a commercial product. Washenik, of the Philadelphia-based Aderans institute, said his group's efforts in hair cloning have shown promise so far in mice. He hopes studies in people can begin next year. He said follicles that grow from the transplanted cells should resist balding, because they come from a part of the head that balding doesn't touch. Ordinary hair transplants show that follicles from these resistant regions stay resistant even when planted in bald regions, he said. But even if the transplanted cells do eventually succumb, "you've got years of hair on your scalp that's of benefit to you,'' said Washenik, who also works for a hair transplantation business called Bosley. Ultimately, he said, scientists would love to accomplish the same goal with a cream that can be smeared on the scalp and deliver just the right chemical signals to stimulate new follicles to grow. In any case, he said, it's not just about hair. Hair follicles, after all, are organs. So what's learned from follicle research may help other scientists who are working to regenerate bigger organs like the liver and kidneys, Washenik said. The same notion was expressed by Sinclair, who's testing a skin cream in mice that may alter follicle behavior by fiddling with genes. (He says he can't discuss the results because they are a commercial secret.) Sinclair said follicle research allows scientists to approach not just organ regeneration, but also questions about stem cells, cell growth and gene therapy that may pay off someday in new treatments for diseases like cancer and Alzheimer's. "The idea of growing hair on a bald scalp is only of moderate interest,'' Sinclair said in a telephone interview. "If we find the cure for baldness we're not going to stop studying hair.'' That's just great, Doc. But if you do find the cure for baldness, lots of men would like to know. Sponsored Links Fantastic Four on DVD Prepare for irreverent fun, non-stop action and awesome special effects when a dysfunctional group of superheroes takes the world by storm with their new-found powers. 24 season 4 Emmy nominated for Best Drama series, is an adrenaline rush that never lets up. Now on DVD. Mr. and Mrs. Smith On DVD Today -Smart and sexy. 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ALL RIGHTS RESERVED. -- --> Hair Restoration: What toHair Loss Treatment Web EzineArticles.com Submit Articles Watch the Video -- Members Login Benefits Recent Articles Expert Authors Experts By Location Read Endorsements Editorial Guidelines Author TOS Terms of Service Ezines / Email Alerts Manage Subscriptions EzineArticles RSS Blog Forums About Us What's New Contact Us Affiliates Link To Us Privacy Policy Site Map Search All Options Search Article IDs Search Article Titles Search Articles Search Expert Authors Search Article Keywords Search Article Summary Advanced Search Power Search Email Address: Your Name: Got an Ezine Marketing or Email Newsletter Question? AskChrisKnight.com HOME :: Health-and-Fitness / Hair-Loss Hair Loss Treatment By Michael Russell Article Word Count: 522 [ View Summary ] Comments (0) In this article we're going to discuss the options for people who suffer from hair loss, assuming their hair does not grow back naturally. In the old days there weren't many options at all. The most common thing to do if you were a man suffering from hair loss was to go out and buy a toupee. Depending on how severe your hair loss was this was either a partial toupee, covering the top or front of the scalp or a full blown wig covering the whole head. If this is still your preferred method of covering up your hair loss it would be best to get a very expensive toupee. Cheap ones look like toupees. Expensive ones actually look like real hair and many of them are partially made from real hair. A very realistic toupee can cost you as much as $800 or more. Even cheap ones are not cheap and can run well over $150 but cheap ones look terrible and you'll look worse than if you just went with no hair at all. After the toupee there are a number of hair loss treatments. One type of hair loss restoration is non surgical bio matrix. This is a process where real human hair is added to your hair by a process where the hair is woven together with your own. They do this in the areas where you are balding so that when you actually comb your hair you'll still see your scalp because the hair is not surgically implanted. This is one of the most popular methods today. Another option is what is called microscopic follicular unit hair transplants. A follicular unit is how hair actually grows, in groupings. A single unit can contain one to four hair follicles. These units also contain hairs that are not visible to the naked eye. Basically hair is transplanted into these invisible units. This method is said to have the highest growth rate and is the most effective for curing baldness. Another option is Extreme Hair Therapy (EXT). EXT stimulates growth of hair in the balding areas. The way this method works is it keeps the hair follicles in their growth stage longer than normal which stimulates thicker hair growth and slows down the thinning process. This process is done at three levels. One, it improves scalp circulation and blood flow. Two, it reduces damage to the hair follicle by reacting with environmental factors. Three, it uses advanced hair loss therapies from around the world as they emerge. Then of course there are your drugs like Minoxidil. This drug was actually an accident. It was first made to treat high blood pressure and they found out that one of the side effects was the ability to slow down or reverse the balding process. By applying this externally at about a 2% solution it actually starts to grow hair. This drug is now marketed under the name of Rogaine. The success of this drug however is limited and then there is always the option of staying bald. Be proud of your dome. ------------------------------------------------------- Michael Russell Your Independent guide to Hair Loss ------------------------------------------------------- Article Source: http://EzineArticles.com/?expert=Michael_Russell Additional EzineArticles from the Health-and-Fitness:Hair-Loss Category: The Shocking Truth About Female Hair Loss Hair Loss -A Discussion Top 10 Myths About Hair Loss Female Hair Loss Treatment and Information Facts for Men and Women Experiencing Hair Loss Hair Loss Remedies Around the Globe Natural Hair Loss Prevention and Treatment Options for Hair Loss Hair Loss - What Causes It? Hair Loss - How To Deal With It Emotionally Useful Tips for Successful Hair Loss Treatment Sudden Hair Loss: The Stress Factor Part I Hair Loss Basic Understanding Beating Hair Loss and Also Understanding How it Comes About Hair Replacement 10 Things You Need to Know When Considering a Hair Replacement Is My Hair Loss Temporary? Laser Hair Removal Know The Facts Hair Restoration: What to Expect Stem Cell Therapy For Hair Loss Vitamins for Hair Loss - The Wow Factor - Dramatic Hair Regrowth in Men and Women Innovations in Hair Transplant and Other Alternatives to Hair Loss Hair Replacement Is a Transplant the Answer? Hair Loss Factors Home Hair Loss Remedies Avoid Drug Side Effects Natural Hair Loss Treatments The Best in Hair Removal Options for You Medical Hair Restoration the Best Choice Hairloss Treatments Ancient Treatments Still Work Today Hair Loss Treatments - What Makes Sense Coping with Female Hair Loss Stop Losing Your Hair Now! 5 Tips to Eliminating Women's Facial Hair Hair Loss and Your Health This article has been viewed 103 time(s). Article Submitted On: December 20, 2005 Please Rate This Article: Select Rating Excellent Very Good Interesting Fair Could Use Improvement Number of ratings: 0 Rating: 0 © EzineArticles.com - All Rights Reserved Worldwide. EzineArticles.com is a Member of the EmailUniverse.com Network Hair Transplant For Self-ImageHair Transplant For Self-Image Web EzineArticles.com Submit Articles Watch the Video -- Members Login Benefits Recent Articles Expert Authors Experts By Location Read Endorsements Editorial Guidelines Author TOS Terms of Service Ezines / Email Alerts Manage Subscriptions EzineArticles RSS Blog Forums About Us What's New Contact Us Affiliates Link To Us Privacy Policy Site Map Search All Options Search Article IDs Search Article Titles Search Articles Search Expert Authors Search Article Keywords Search Article Summary Advanced Search Power Search Email Address: Your Name: Got an Ezine Marketing or Email Newsletter Question? AskChrisKnight.com HOME :: Health-and-Fitness / Hair-Loss Hair Transplant For Self-Image By Kenneth Snodin Article Word Count: 446 [ View Summary ] Comments (0) Hair transplant is one way that many are gaining their self-esteem back. Self-Image is a very important thing to have. To an extent, it dictates where you are going in life. Your self-image is made up of more than just your physical appearance, but that is a major component. If it takes hair transplant to get you back on a positive attitude in that regard, then you should do it. Some men are perfectly content with less hair than they once had. Some are even lucky enough to look good bald. Unfortunately, these are the few. The rest of the many people who are losing their hair are losing their looks and confidence too. When you have plenty of confidence, you show it. People know that you mean business and that you expect to get what you want and need. And you usually do. However, when you walk into a place worrying how you look, or doubting yourself, you arent likely to project a strong image. And you are much less likely to get what you need, want, and deserve. This is why many people turn to hair transplant options. If having a full head of hair again will give you that confidence you need to get around in life, then you should pursue it. Not for anyone else, but for you. Before you decide to do hair transplant, you should look at your options. If a wig is all you need, more power to you. However, many wigs look way to obvious to do a lot of good in this area. You can also talk to your doctor about treatments for natural hair re-growth. However, make sure that you understand all possible side-effects before you start taking it. When all else fails, there are hair transplant options. And thanks to modern technology, it is actually possible without scarring. But before you commit, make sure that you know what you are getting yourself into. Find out what can go wrong, and what your chances are. Also ask about how long the procedures will take and any recovery times. Be informed. Next, you should find out who you want to do it. Look at people who do hair transplant options and find out about them. You can even go visit with them and ask to see previous work that they have done if they have it available. If you know anyone who has had it done, see who they would or wouldnt recommend. After you have all the information that you can get, go and retrieve your self-confidence with hair transplant technology. Get more of your questions answered at http://www.best-hairtransplant.info about Hair Transplants . Article Source: http://EzineArticles.com/?expert=Kenneth_Snodin Additional EzineArticles from the Health-and-Fitness:Hair-Loss Category: The Shocking Truth About Female Hair Loss Hair Loss -A Discussion Top 10 Myths About Hair Loss Female Hair Loss Treatment and Information Facts for Men and Women Experiencing Hair Loss Hair Loss Remedies Around the Globe Natural Hair Loss Prevention and Treatment Options for Hair Loss Hair Loss - What Causes It? Hair Loss - How To Deal With It Emotionally Hair Loss Treatment Useful Tips for Successful Hair Loss Treatment Sudden Hair Loss: The Stress Factor Part I Hair Loss Basic Understanding Beating Hair Loss and Also Understanding How it Comes About Hair Replacement 10 Things You Need to Know When Considering a Hair Replacement Is My Hair Loss Temporary? Laser Hair Removal Know The Facts Hair Restoration: What to Expect Stem Cell Therapy For Hair Loss Vitamins for Hair Loss - The Wow Factor - Dramatic Hair Regrowth in Men and Women Innovations in Hair Transplant and Other Alternatives to Hair Loss Hair Replacement Is a Transplant the Answer? Hair Loss Factors Home Hair Loss Remedies Avoid Drug Side Effects Natural Hair Loss Treatments The Best in Hair Removal Options for You Medical Hair Restoration the Best Choice Hairloss Treatments Ancient Treatments Still Work Today Hair Loss Treatments - What Makes Sense Coping with Female Hair Loss Stop Losing Your Hair Now! 5 Tips to Eliminating Women's Facial Hair This article has been viewed 47 time(s). Article Submitted On: December 13, 2005 Please Rate This Article: Select Rating Excellent Very Good Interesting Fair Could Use Improvement Number of ratings: 0 Rating: 0 © EzineArticles.com - All Rights Reserved Worldwide. EzineArticles.com is a Member of the EmailUniverse.com Network treat hair loss, woundsGenuine stem cells found in skin might treat hair loss, wounds Public release date: 2-Sep-2004 [ | E-mail Article ] Contact: Heidi Hardman hhardman@cell.com 617-397-2879 Cell Press Genuine stem cells found in skin might treat hair loss, wounds Master cells nestled within hair follicles of the skin retain the ability to form new hairs as well as skin, new research reported in the September 3 issue of Cell confirms. While earlier work had suggested the presence of stem cells in skin, the new study by Howard Hughes Medical Institute investigators at Rockefeller University in New York provides the first direct evidence that cells extracted from the hair follicles of mice exhibit all of the defining features of true stem cells. The skin stem cells offer potential new methods to reverse baldness and boost wound healing in burn victims and those suffering from other skin injuries, the researchers said. The putative skin stem cells reproduce themselves seemingly indefinitely in the laboratory, the study found. When engrafted onto the backs of hairless mice, the cells also formed stretches of skin, tufts of hair, and sebaceous glands, which secrete an oily substance known as sebum that lubricates skin and hair. "We've identified cells within skin that bear all the characteristics of true stem cells--the ability for self renewal and the multipotency required to differentiate into all lineages of epidermis and hair," said Elaine Fuchs, cell biologist at Rockefeller University and senior author of the study. "The results demonstrate for the first time that individual cells isolated from hair follicles can be cultured in the laboratory and retain a capacity to make multiple cell types when grafted." The team's analysis of the versatile skin cells also offers new insights into the underlying genetic signature common to all stem cells, said the researchers. Stem cells are undifferentiated cells whose daughters give rise to the specialized cell types that make up an organism. Embryonic stem cells, which emerge in the first days of an embryo's development, have the potential to differentiate, or specialize, into each of the 200 types of tissue in the body. In contrast, adult stem cells found in tissues throughout the body--including bone marrow, muscle, and skin--are defined by the ability to reproduce themselves and give rise to the full complement of cells that make up the specialized tissue in which they are found. By harnessing stem cells' natural capacity for replenishing cells, scientists hope to advance on new therapies designed to repair or replace damaged tissues and organs, said the researchers. In mammalian skin, each hair follicle contains a reservoir of stem cells, known as the bulge, which can be mobilized to regenerate the new follicle with each hair cycle and to generate new epidermis during wound repair, the team explained. Using new avenues to probe the cellular architecture of stem cells within the natural environment, or niche, of the hair follicle, the researchers discovered two distinct populations of resident cells within the bulge--one attached and one detached from the underlying extracellular matrix known as the basal lamina. New methods devised by the team then allowed them to isolate those two cell types for independent examination of their behavior and molecular properties. While both cell types exhibited growth inhibition within their niche, the two underwent stem cell self-renewal in laboratory dishes, a quality that could prove clinically useful if it holds for stem cells derived from haired human skin, said Fuchs. Furthermore, clonal analyses revealed that both populations contained multipotent stem cells able to differentiate into all lineages of epidermis and hair following engraftment onto the backs of hairless mice. Remarkably, the graft even included formation of a structure within the follicle sharing many features of the stem cell niche, the team reported. The two stem cell populations within the bulge exhibited significant differences in the activity of some genes. However, the team also found that about 14 percent of genes upregulated in embryonic, bone marrow, and neuronal stem cells also showed heightened activity in both groups of stem cells in the skin, further delineating the short list of "stemness" genes. "These new data now document that single cells isolated from the bulge can self-renew and are multipotent, and thus possess the classical defining features of bona fide stem cells," according to the study's lead authors Cedric Blanpain and William Lowry, also of Rockefeller University. Although their studies have so far been restricted to mice, the presence of such cells in the skin holds promise for regenerative medicine with regard to hair loss and wound healing, the researchers added. Once the essential genetic differences that distinguish embryonic and adult stem cells come to light, they said, the more accessible stem cells in skin might ultimately prove useful in the future for generating tissues lost in certain other types of diseases, such as some forms of blindness, or possibly even diabetes or Parkinson's. "With debate about the cells' mutipotency within skin tissue settled, we can now ask whether the stem cells can also make other cell types in addition to hair and skin," Lowry said. "These results open the door to that possibility." ### Cedric Blanpain, William E. Lowry, Andrea Geoghegan, Lisa Polak, and Elaine Fuchs: "Self-Renewal, Multipotency, and the Existence of Two Cell Populations within an Epithelial Stem Cell Niche" Published in Cell, Volume 118, Number 5, September 3, 2004, pages 635-648. [ | E-mail Article ] Jennifer Aniston HairBrad Pitt, Jennifer Aniston: Brad Pitt, Jennifer Aniston Back Together? Search Navigation Home Celebrity Home Celebrity News All Celebrity News Auf Deutsch Celebrity Fashion Clothes Womens-Wear Tops Jeans Interviews Celebrity Interviews Music News Music Reviews Entertianment Latest News Movie News Film Reviews Games Celebrity Love Match Celebrity Pairs Celebrity Hangman Do Scary Movies Scare You? Yes I watch them with the light on. No I can watch them in the dark. Not at all they make me laugh Brad Pitt, Jennifer Aniston Back Together? February 3, 2005, 12:38:19 Brad Pitt and Jennifer Aniston are still living together - fuelling yet more speculation their split is not permanent. It had been reported that the former 'Friends' beauty had moved out of the Hollywood home she shared with the heartthrob actor and was living with her hair stylist, Chris McMillan. It was also claimed that Jennifer was set to move back into the home she lived in before she married Brad and had asked 'Ali G' star Sacha Baron Cohen and his fiance, Isla Fisher, who had been renting it, to move out. However, Jennifer's spokesman says there is no truth in either story, but refused to comment on whether the couple were sharing a bedroom.He said: "Jennifer never stayed with her hair stylist, Chris McMillan, after the separation was announced. "All I can say is that Brad and Jennifer remain caring and loving friends." Earlier this week, Brad's grandmother, Betty Russell, said the couple would get back together as she believes they are only on a trial separation. She told Britain's More magazine: "I'm sure this is just a temporary thing. Brad and Jennifer are beautiful people. They've always been so happy. ** Article Continues Below ** ** The Brad Pitt, Jennifer Aniston article continues now ** "They have too much love to throw it all away. They just need to spend a little time apart before they realise how much they miss each other. I'm praying for it." Brad and Jennifer were also reported to have enjoyed a romantic mealtogether. The couple, who pledged to remain "committed and caring friends" when they split, dined at top Los Angeles restaurant L'Orangerie, looking relaxed and happy in each other's company. Tell your friend about this story, Get the best daily celebrity gossip headlines! 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